GABAergic neuron-to-glioma synapses in diffuse midline gliomas
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08579-3
Functional, tumour-promoting GABAergic neuron-to-glioma synapses in diffuse midline gliomas are identified.Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis
Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08591-1
Functional connectivity between gastric cancer cells and sensory neurons offers a potential therapeutic target.Thermal Ca<sup>2+</sup>/Mg<sup>2+</sup> exchange reactions to synthesize CO<sub>2</sub> removal materials
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08499-2
Reactions of Mg-rich silicates with calcium carbonates/sulfates result in the formation of materials that could potentially be used for low-cost carbon dioxide removal from the atmosphere.Modulated ringdown comb interferometry for sensing of highly complex gases
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08534-2
A new optical technique, modulated ringdown comb interferometry, is introduced for measuring the concentration of gas species in a complex sample and its efficacy demonstrated using exhaled human breath and ambient air in the mid-infrared.Perovskite heteroepitaxy for high-efficiency and stable pure-red LEDs
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08503-9
A heteroepitaxial-strain-based strategy for enhancing the stability of perovskite quantum dots for spectrally narrow (pure) red LEDs is reported.Global modules robustly emerge from local interactions and smooth gradients
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08541-3
The principle of peak selection is described, by which local interactions and smooth gradients drive self-organization of discrete global modules.SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08574-8
A biochemical system recapitulates the hallmarks of meiotic double-strand break formation, with mouse SPO11 catalysing break formation in the absence of any partners and remaining covalently attached to 5′ broken strands.Interferometric single-shot parity measurement in InAs–Al hybrid devices
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08445-2
A device architecture based on indium arsenide–aluminium heterostructures with a gate-defined superconducting nanowire allows single-shot interferometric measurement of fermion parity and demonstrates an assignment error probability of 1%.Reply to: Insufficient evidence for natural selection associated with the Black Death
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08497-4
Reply to: Insufficient evidence for natural selection associated with the Black DeathIn vitro reconstitution of meiotic DNA double-strand-break formation
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08551-1
The in vitro characterization of a key event in the early stages of meiosis—the induction of double-strand DNA breaks by the SPO11–TOP6BL complex—provides insight into the catalytic mechanism and evolution of SPO11.Reconstitution of SPO11-dependent double-strand break formation
Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08601-2
Reconstitution of recombinantly expressed SPO11–TOP6BL complex recapitulates its DNA cleavage function and together with structural modelling and biochemical experiments, provides insights into the regulation and mechanism of SPO11 activity.Scale dichotomization reduces customer racial discrimination and income inequality
Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08599-7
Changing from a five-point scale to a two-point scale for rating workers reduces racial discrimination by making customers focus on whether the work was good or bad instead of their own personal biases.Hypotaxy of wafer-scale single-crystal transition metal dichalcogenides
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08492-9
A new method ‘hypotaxy’ enables wafer-scale, single-crystal transition metal dichalcogenides growth directly on crystalline, lattice-mismatched and amorphous substrates.An opponent striatal circuit for distributional reinforcement learning
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08488-5
D1- and D2-expressing striatal neurons encode separate parts of a learned reward distribution, paralleling modern approaches in machine learning.Human-correlated genetic models identify precision therapy for liver cancer
Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08585-z
As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in a highly effective subtype-specific manner in combination with standard-of-care therapy.Spontaneous ordering of identical materials into a triboelectric series
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08530-6
Nominally identical materials are found to spontaneously order into triboelectric series over repeated processes, which is found to be driven by the act of contact itself using experiments as well as numerical simulations.Cooperative nutrient scavenging is an evolutionary advantage in cancer
Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08588-w
Nutrient-starved tumour cells cooperate by secreting aminopeptidases that digest oligopeptides in the microenvironment, creating a shared pool of free amino acids.Endogenous DNA damage at sites of terminated transcripts
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08578-4
Transcription termination or pausing during DNA replication in bacteria and humans results in DNA damage with exposed 3′ single-stranded DNA ends and mutations.Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1
Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08590-2
We find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, mitochondrial abnormalities and innate immune responses.Tumour-wide RNA splicing aberrations generate actionable public neoantigens
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08552-0
A study identifies public neoantigens generated by tumor-wide aberrant mRNA splicing activity across distinct cancer types.