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Exclusive: NIH to suspend funds for research abroad as it overhauls policy
Nature, Published online: 30 April 2025; doi:10.1038/d41586-025-01361-z
Move by US biomedical agency threatens thousands of projects on infectious diseases, cancer and more.One of the world’s richest lithium deposits began inside a mega-volcano
Nature, Published online: 30 April 2025; doi:10.1038/d41586-025-01273-y
Lithium that pooled in a volcanic caldera in the western United States had no way out, thanks to a lack of rivers.A DNA-gated molecular guard controls bacterial Hailong anti-phage defence
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-09058-z
A DNA-gated molecular guard controls bacterial Hailong anti-phage defenceA MERS-CoV-like mink coronavirus uses ACE2 as entry receptor
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-09007-w
A MERS-CoV-like mink coronavirus uses ACE2 as entry receptorThe dismantling of US science: can it survive Trump 2.0?
Nature, Published online: 30 April 2025; doi:10.1038/d41586-025-01381-9
In the face of massive upheaval, what is the long-term outlook for science in the US and beyond?Nickel production is notoriously dirty — here’s how to make it greener
Nature, Published online: 30 April 2025; doi:10.1038/d41586-025-01356-w
If scaled up, a method for extracting nickel without using carbon-rich coke could reduce emissions considerably.Metal-centred planar [15]annulenes
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08841-2
An aromatic metallo-annulene, comprising a 15-carbon macrocycle enclosing an osmium complex, with the metal residing within the plane of the macrocycle is reported.Adversarial testing of global neuronal workspace and integrated information theories of consciousness
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08888-1
Multimodal results (iEEG, fMRI and MEG) of predictions from integrated information theory and global neuronal workspace theory align with some predictions of both theories on visual consciousness, but also critically challenge key tenets of both theories.Diet outperforms microbial transplant to drive microbiome recovery in mice
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08937-9
Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic interactions that occur only with specific dietary interventions.TIR domains produce histidine-ADPR as an immune signal in bacteria
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08930-2
In response to phage infection, the Toll/interleukin-1 receptor (TIR) domain protein ThsB of the type II Thoeris defence system produces histidine conjugated to ADP-ribose, which stimulates bacterial defence by interacting with the Macro domain of the ThsA membrane effector protein.Cell cycle duration determines oncogenic transformation capacity
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08935-x
Total cell cycle duration is a key hallmark of cancer initiation, and determines whether defects in apoptosis, senescence, immune surveillance, angiogenesis, DNA repair, polarity and proliferation lead to cancer development.Structurally complex phase engineering enables hydrogen-tolerant Al alloys
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08879-2
A size-sieved complex precipitation in Sc-added Al–Mg alloys achieves a high-density dispersion of both fine Al3Sc nanoprecipitates and in situ formed core-shell Al3(Mg, Sc)2/Al3Sc nanophases with high hydrogen-trapping ability.Picuris Pueblo oral history and genomics reveal continuity in US Southwest
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08791-9
A collaborative study initiated by the sovereign nation of Picuris Pueblo in the Northern Rio Grande region of New Mexico addresses gaps in traditional knowledge and furthers understanding of their population history and ancestry.Global evolution of inflammatory bowel disease across epidemiologic stages
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08940-0
An analysis of data from 522 population-based studies encompassing 82 global regions and spanning more than a century (1920–2024) shows spatiotemporal transitions across epidemiologic stages 1 to 3 of inflammatory bowel disease, and models stage 4 progression.The distribution of subsurface microplastics in the ocean
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08818-1
Global data collected between 2014 and 2024 provide insights into the distribution and potential transport mechanisms of subsurface microplastics throughout the oceanic water column.Pacific hotspots reveal a Louisville–Ontong Java Nui tectonic link
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08889-0
Geochemistry and geochronology show that Samoa and Rurutu–Arago are the longest-lived Pacific hotspots, providing better constraints on plate rotation and support for a link between the Louisville volcanic track and the Ontong Java Nui Plateau.Regulation of PV interneuron plasticity by neuropeptide-encoding genes
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08933-z
Increasing the activity of individual parvalbumin-expressing interneurons in the mouse brain modulates the number and strength of inhibitory parvalbumin synapses received by these cells through changes in the expression of the neuropeptide-encoding genes Vgf and Scg2.Using life cycle assessment to drive innovation for sustainable cool clouds
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08832-3
A life cycle assessment study is used to examine the impacts of advanced cooling technologies on cloud infrastructure, from virtual machines to server architecture, data centre buildings and the grid.Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08945-9
Inhibition of a cardiac stroma-enriched mechanosensor, SRC—in concert with suppression of the TGFβ pathway—potentiates the reversal of fibroblast activation and alleviates contractile dysfunction in fibrotic hearts.Serotonin and neurotensin inputs in the vCA1 dictate opposing social valence
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08809-2
Aversive and rewarding social experiences are linked to conspecific identity through converging dorsal raphe 5-HT and paraventricular nucleus of the thalamus neurotensin signals in the vCA1 that instruct opposing valence, representing a synaptic switch for flexible social valence computation.