Generation of human adult hepatocyte organoids with metabolic functions
Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08861-y
The combined activation of Wnt and STAT3 signalling enables long-term self-renewal of human hepatocyte organoids, maintaining hepatic identity, supporting gene editing and offering therapeutic potential for liver disease through enhanced functionality, structure and metabolic competency.Deep Visual Proteomics maps proteotoxicity in a genetic liver disease
Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08885-4
High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing early peroxisomal activation and late-stage proteotoxic phenotypes.Wide-swath satellite altimetry unveils global submesoscale ocean dynamics
Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08722-8
Data from the recently launched Surface Water and Ocean Topography satellite reveal the characteristics of submesoscale eddies and waves and suggest that their potential impacts on overall ocean circulation is much larger than previously thought.Low overlap of transcription factor DNA binding and regulatory targets
Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08916-0
A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between their binding sites on DNA and regulation of nearby genes.Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease
Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08845-y
Bilateral grafts of cryopreserved human embryonic stem cell-derived dopaminergic neuron progenitor cells into the putamen of patients with Parkinson’s disease in a phase I clinical trial showed safety, improvements in off-drug motor function and graft survival at 18 months after transplant.Negative thermal expansion and oxygen-redox electrochemistry
Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08765-x
Using operando electrochemical processes, we found a way to restore oxygen-redox active materials exhibiting structural and voltage decay to their pristine state, providing a framework for the design of functional materials with zero thermal expansion.Reframe perspectives on Alzheimer’s disease
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01100-4
Advances in diagnosis and treatment mean that rapid cognitive decline won’t necessarily follow hot on the heels of a diagnosis.Roses are red — but their ancestors were yellow
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01107-x
A genomic analysis of 84 species in the genus Rosa traces the evolutionary history of the beloved flower.Faster, cheaper, better: the rise of blood tests for Alzheimer’s
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01105-z
Circulating biomarkers are quickly becoming a crucial part of diagnosis and disease monitoring for physicians, researchers — and even some consumers.How a hydrogen lab is helping to power Spain’s green-energy shift
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01025-y
Cost is key in the drive to ‘defossilize’ Spain’s energy needs as the country faces the devastating impacts of climate change.The unusual genetic inheritance that could change Alzheimer’s treatment
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01103-1
The genes of a Colombian woman who beat the odds might lead to a new way to tackle the disease.First global pandemic treaty agreed — without the US
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-00839-0
The World Health Organization accord promotes sharing scientific data in exchange for more equitable distribution of drugs and vaccines.Alzheimer’s disease: highlights from research
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01101-3
The ‘dark’ cells behind disease, how diabetes drugs might protect cognitive function, and other studies and trials.Why women experience Alzheimer’s disease differently from men
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01106-y
Sex and gender research could lead to better, more equitable treatments — if it is allowed to continue without political interference.Science on our sleeves: the research that inspires our tattoos
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-00721-z
Inked scientists choose scientific images to mark career accomplishments and illustrate their research passion.Healthy soil is the hidden ingredient — here’s how I’m fighting to save it
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01026-x
Around 60% of the European Union’s soils are considered unhealthy, but geographer Jesús Rodrigo Comino is determined to help change that in his native Spain.Meet the researchers pioneering Spanish climate solutions
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01149-1
Spain is feeling the heat. Four researchers share how climate change shapes their work and their fight for a sustainable future.Do infections have a role in Alzheimer’s disease?
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01104-0
The suggestion that pathogens play a part in driving dementia is not as niche as it once was, but the evidence remains inconclusive.The future of Alzheimer’s treatment
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01102-2
Drugs that clear away brain plaques are a welcome arrival, but targeting amyloid alone might not be enough to halt the disease.Spain adapts to new reality as climate crisis hits home
Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01003-4
Country doubles down on climate pledges in the wake of devastating floods.