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Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08980-6

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08823-4

A. J. Eisfeld et al. reply

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08822-5

Receptor-binding specificity of a bovine influenza A virus

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08649-0

Natively expressed AcrIII-1 does not function as an anti-CRISPR protein

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08821-6

Bovine H5N1 binds poorly to human-type sialic acid receptors

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08843-0

A haplotype-resolved pan-genome of autotetraploid European potato founder lines shows high nucleotide diversity at remarkably low haplotype diversity, which is probably the result of hybridization events with wild potato species, followed by population bottlenecks during domestication and transition to Europe.

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08871-w

Dnmt3a mutations in mouse haematopoietic stem and progenitor cells equivalent to R882 mutations in human cause increased mitochondrial respiration, suggesting that this is a mechanism of clonal haematopoiesis and a potential therapeutic target.

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08812-7

Experimental and theoretical exploration of domain walls forming in wurtzite ferroelectrics following the application of electric fields demonstrates their reconfigurable conductivity as well as tunability, showing potential for use in ultrascaled devices.

Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01046-7

Neutron-scattering experiments have revealed a predicted high-pressure phase of ice called ‘plastic ice VII’, in which molecules form crystals, as they do in normal ice, but rotate as in liquid water. These data highlight the role of hydrogen dynamics in defining exotic ice phases and could have implications for the geodynamics of icy planets.

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08850-1

Liver organoids derived from human induced pluripotent stem cells populations grown with ascorbate and bilirubin can be used to recapitulate differential zonal functions of human hepatocytes and for transplantation in animal models of liver dysfunction.

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08883-6

A pangenome of wild and cultivated rice accessions captures the entire set of non-redundant genes and diversity in rice, and provides insights into the pathways involved in the evolution of rice.

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08890-7

The structure and function of the MCR activation complex from Methanococcus maripaludis were revealed, demonstrating its ATP-dependent ability to activate MCR and form methane while uncovering a unique electron transfer pathway involving iron–sulfur clusters similar to the nitrogenase cofactor intermediates.

Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01129-5

Metformin could reduce people’s risk of certain age-associated blood cancers, but more work is needed to identify who is likely to benefit.

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08834-1

A method, RARE-seq, for sensitive detection of cell-free RNAs in blood is demonstrated to have diverse clinical applications including diagnosing and characterizing human cancers, and tracking response to RNA therapeutics.

Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01176-y

Potential treatments need to be subject to the highest standards of safety and efficacy.

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08862-x

The dynamical axion quasiparticle, which is directly analogous to the hypothetical fundamental axion particle, is observed in two-dimensional MnBi2Te4, and has implications for quantum chromodynamics, cosmology and string theory.

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08839-w

A two-dimensional Dirac graphene-channel flash memory based on a two-dimensional-enhanced hot-carrier-injection mechanism that supports both electron and hole injection is used to make devices with a subnanosecond program speed.

Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-00688-x

Transplanting dopamine-releasing neurons into the brain is a promising regenerative therapy for Parkinson’s disease. Two clinical trials show that it is safe, but more evidence is needed to prove its effectiveness.

Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08775-9

Seismic reflection imaging beneath the northeastern Yellowstone caldera reveals a sharp boundary at about 3.8 km depth, which is inferred to result from a mixture of supercritical fluid and magma filling the pore space.

Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01143-7

Induced pluripotent stem cells are being tested to treat blindness, paralysis, Parkinson’s disease and more. Approvals might be around the corner.