Daily briefing: AI-designed proteins offer lifeline for treating snake bites
Nature, Published online: 16 January 2025; doi:10.1038/d41586-025-00163-7
Artificial intelligence-designed proteins could block the deadly effects of snake venom. Plus, who are science’s winners and losers under Trump 2.0?Brain-wide neuronal circuit connectome of human glioblastoma
Nature, Published online: 16 January 2025; doi:10.1038/s41586-025-08634-7
Brain-wide neuronal circuit connectome of human glioblastomaTrump will weaken climate action — the rest of the US must not follow suit
Nature, Published online: 16 January 2025; doi:10.1038/d41586-025-00148-6
Researchers, governments and others can all play a part in ensuring climate policies remain in the interest of all.A generative model for inorganic materials design
Nature, Published online: 16 January 2025; doi:10.1038/s41586-025-08628-5
XXX.Championing queer scientists of colour: ‘I don’t think we’ve scratched the surface on systemic exclusion’
Nature, Published online: 16 January 2025; doi:10.1038/d41586-024-04069-8
Arachnologist Lauren Esposito develops community platforms to share LGBTQ+ voices and wants to shed light on the overlooked intersectional barriers affecting queer people of colour.Daily briefing: New obesity definition sidelines BMI to focus on health
Nature, Published online: 15 January 2025; doi:10.1038/d41586-025-00147-7
Researchers offer a more nuanced definition of obesity. Plus, two private Moon missions launch at the same time.Author Correction: Evolution of immune genes is associated with the Black Death
Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08522-6
Author Correction: Evolution of immune genes is associated with the Black DeathHidden tattoos on mummy skin emerge under a laser’s light
Nature, Published online: 15 January 2025; doi:10.1038/d41586-025-00043-0
Blurry markings more than 1,000 years old become clear again thanks to scanning method.Got flu? Promising drug shortens symptoms
Nature, Published online: 15 January 2025; doi:10.1038/d41586-025-00041-2
Influenza viruses have not evolved resistance to suraxavir marboxil, which relieves cough, fever and other symptoms.Will Europe ramp up defence research? War prompts major rethink
Nature, Published online: 15 January 2025; doi:10.1038/d41586-025-00117-z
Nations consider increasing universities’ involvement in military research.<b>Meta AI creates speech-to-speech translator that works in dozens of languages</b>
Nature, Published online: 15 January 2025; doi:10.1038/d41586-025-00045-y
Machine-learning system can process words spoken in 101 languages, spitting out voice-synthesized translations in 36 target languages.Engineered enzymes for enantioselective nucleophilic aromatic substitutions
Nature, Published online: 15 January 2025; doi:10.1038/s41586-025-08611-0
Engineered enzymes for enantioselective nucleophilic aromatic substitutionsPathogenesis of bovine H5N1 clade 2.3.4.4b infection in Macaques
Nature, Published online: 15 January 2025; doi:10.1038/s41586-025-08609-8
Pathogenesis of bovine H5N1 clade 2.3.4.4b infection in MacaquesAI-designed antivenoms could help treat lethal snakebites
Nature, Published online: 15 January 2025; doi:10.1038/d41586-025-00134-y
Proteins made using machine learning successfully bind snake toxins — plus, Earth’s temperature breaks a significant climate threshold for the first time.Episodic and associative memory from spatial scaffolds in the hippocampus
Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08392-y
A neocortical–entorhinal–hippocampal network model based on grid cell states recapitulates experimental results and reconciles the spatial, associative and episodic memory roles of the hippocampus.All-solid-state Li–S batteries with fast solid–solid sulfur reaction
Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08298-9
By using lithium thioborophosphate iodide glass-phase solid electrolytes in all-solid-state lithium–sulfur batteries, fast solid–solid sulfur redox reaction is demonstrated, leading to cells with ultrafast charging capability, superior cycling stability and high capacity.Continental influx and pervasive matrilocality in Iron Age Britain
Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08409-6
An analysis of ancient mitochondrial and nuclear DNA shows evidence of matrilocal communities in Iron Age Britain.Targeting protein–ligand neosurfaces with a generalizable deep learning tool
Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08435-4
A computational deep learning approach is used to design synthetic proteins that target the neosurfaces formed by protein–ligand interactions, with applications in the development of new therapeutic modalities such as molecular glues or cell-based therapies.Prolonged persistence of mutagenic DNA lesions in somatic cells
Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08423-8
Persistent DNA lesions can occur throughout the human lifespan and can remain in the genome of affected cells for several years and generate a substantial proportion of the mutational burden.The human and non-human primate developmental GTEx projects
Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08244-9
The developmental Genotype-Tissue Expression (dGTEx) projects will catalogue and integrate gene expression, regulation and genetics data across 120 human donors from birth to adulthood with developmentally matched non-human primates, including 126 rhesus macaques and 72 common marmosets.