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Nature, Published online: 22 January 2025; doi:10.1038/s41586-024-08441-6

A non-invasive in vivo positron emission tomography imaging approach detects inflammatory disease using various preclinical models.

Nature, Published online: 22 January 2025; doi:10.1038/s41586-024-08239-6

We report signatures of a generalized version of the anomalous Hall crystal in twisted bilayer–trilayer graphene, whose formation is driven by the moiré potential.

Nature, Published online: 22 January 2025; doi:10.1038/s41586-024-08406-9

A proof-of-principle study reports a complete photonic quantum computer architecture that can, once appropriate component performance is achieved, deliver a universal and fault-tolerant quantum computer.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00176-2

Immune cells lose their cancer-fighting prowess after taking tumours’ organelles on board.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00077-4

Immune cells can destroy cancer, but tumours often evade such responses. The bidirectional transfer of mitochondria between cancer and immune cells is a newly discovered mechanism that thwarts anticancer defences.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00143-x

Huge analysis identifies regional variations in the criteria that institutions use to move researchers up the ranks.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00078-3

A rapid and efficient method developed to create stem-cell-based 3D mini-organs derived from the cells of patients offers a way to evaluate personalized treatments using RNA therapies for rare genetic diseases.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00101-7

A multi-ancestry genome-wide study of 158,036 people with bipolar disorder and 2,796,499 control individuals identified 298 genomic regions associated with the disease. Variations in 36 genes were linked to the condition, and this variation was enriched in certain neuronal cell populations. The genetic architecture underlying bipolar disorder varied with subtype and how cases were identified.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00104-4

Rubisco is the enzyme responsible for carbon fixation in plants, algae and many bacteria. A screen of a comprehensive library of rubisco variants (each with a different single-amino-acid mutation), expressed in engineered bacteria, identifies several mutations that improve the enzyme’s affinity for carbon dioxide.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00095-2

In certain crystals, quasiparticles called Weyl fermions emerge from the collective quantum behaviour of electrons. However, these quasiparticles typically coexist with undesired conventional electronic states. After a decade-long search, physicists have engineered a crystal without conventional electronic states and with quantum properties governed entirely by Weyl fermions. Such materials could be useful for detecting and generating terahertz light.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00107-1

Moscot is a cell-mapping framework based on the concept of optimal transport. It can analyse large-scale single-cell data, enabling mapping of the developmental trajectories of individual cells in and across organs. Moscot is scalable to millions of cells, and can track several cell characteristics simultaneously in space and time.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00079-2

Older female mice show poor spatial memory when their paternal X chromosome is inactive and only the maternal copy is active. This phenomenon could be responsible for variation in age-related cognitive decline among women.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00206-z

Huge study highlights global discrepancy in hiring requirements — plus, how cancer cells palm-off misfiring mitochondria to help avoid destruction.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-024-04211-6

Bursts of electromagnetic radiation that share similarities with birdsong have long been observed close to Earth. A detection farther out in space confirms a key part of the theory of their origin, but also poses questions.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00098-z

Human genetic diversity and evolution rely on new mutations and exchange of DNA between chromosomes during the generation of sex cells, in a process called recombination. Recombination manifests as large-scale crossovers, and as short-scale transitions called non-crossovers. A map of where recombination occurs throughout the human genome now includes both types of variation.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-024-04252-x

A lack of experienced imaging trainers in her native Uruguay put Marcela Díaz on the path towards mentorship.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00154-8

We’re here to help.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00150-y

Nature asked the world’s largest health-research funders what they are doing to study a life stage experienced by half of humanity. Here is what some of them told us.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00069-4

Researchers are exploring how to prolong ovarian life and revisiting hormone replacement therapy — a once routine treatment that has fallen out of favour.

Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00153-9

Feng ‘Franklin’ Tao says that the University of Kansas violated its own policies after he was wrongly arrested under the China Initiative.