Strange flashes from ancient galaxy deepen mystery of fast radio bursts
Nature, Published online: 29 January 2025; doi:10.1038/d41586-025-00233-w
Unusual detection bolsters evidence that the mysterious signals can be caused by different astrophysical events.Engineered heart muscle allografts for heart repair in primates and humans
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08463-0
Epicardial engineered heart muscle allografts from induced pluripotent stem cell-derived cardiomyocytes can safely and effectively remuscularize chronically failing hearts in rhesus macaques, leading to improved cardiac function and paving the way for human clinical trials.Methanol transfer supports metabolic syntrophy between bacteria and archaea
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08491-w
Zhaonella formicivorans produces methanol, for a novel syntrophic interaction, without requiring methylated compounds as an input.SARS-CoV-2 evolution on a dynamic immune landscape
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08477-8
A modelling approach predicts SARS-CoV-2 variant dynamics on the basis of immunity and cross-neutralization, which was shaped by a region’s SARS-CoV-2 infection history.Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08484-9
Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K.Warming and cooling catalyse widespread temporal turnover in biodiversity
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08456-z
Global-scale analyses of marine, terrestrial and freshwater assemblages found that temporal rates of species replacement were faster in locations with faster temperature change, including warming and cooling, and vulnerable assemblages were especially responsive.C-terminal amides mark proteins for degradation via SCF–FBXO31
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08475-w
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.Copper-dependent halogenase catalyses unactivated C−H bond functionalization
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08362-4
A halogenase enzyme uses the copper in its active site to catalyse iterative chlorinations on multiple unactivated carbon−hydrogen bonds, enabling carbon−hydrogen functionalization that is not achievable with an iron-based halogenase.Signatures of longitudinal spin pumping in a magnetic phase transition
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08367-z
Longitudinal spin pumping is experimentally demonstrated using the magnetic phase transition of iron–rhodium, and the observed inverse spin Hall signal indicates that longitudinal spin pumping is driven by quantum fluctuations.Degradable thermosets via orthogonal polymerizations of a single monomer
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08386-w
Degradable thermoset multimaterials can be synthesized from a commercially accessible, biosourced monomer using orthogonal polymerizations in a single pot; after selective degredation, the resulting small molecules can be repolymerized.Maize monoculture supported pre-Columbian urbanism in southwestern Amazonia
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08473-y
Remote sensing, field survey and microbotanical analyses show that the pre-Columbian Casarabe culture in the Bolivian Amazon invested heavily in landscape engineering, constructing a complex system of drainage canals and newly documented savannah farm ponds.Contrasting drought sensitivity of Eurasian and North American grasslands
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08478-7
Eurasian grasslands have high production sensitivity to extreme drought compared with North American grasslands.Bat genomes illuminate adaptations to viral tolerance and disease resistance
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08471-0
A systematic analysis of 115 mammalian genomes, including 10 new bat genomes, reveals prevalent positive selection in immune genes in bats and shows key adaptations in the antiviral gene ISG15 that aid disease resistance in bats, including to coronaviruses.Expanding the human gut microbiome atlas of Africa
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08485-8
A cross-sectional study from four African countries shows the importance of investigating the gut microbiome in previously under-represented populations and provides a framework for equitable microbiome research.An evaporite sequence from ancient brine recorded in Bennu samples
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08495-6
Samples from the asteroid (101955) Bennu, returned by the OSIRIS-REx mission, include sodium-bearing phosphates and sodium-rich carbonates, sulfates, chlorides and fluorides formed during evaporation of a late-stage brine.The Ronne Ice Shelf survived the last interglacial
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08394-w
Sea salt data from an ice core record show that Antarctica’s Ronne Ice Shelf survived the last interglacial, the last period of enhanced and sustained global warmth about 125,000 years ago.CARD domains mediate anti-phage defence in bacterial gasdermin systems
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08498-3
Caspase recruitment domains (CARDs) are present in defence systems that protect bacteria against phage, where the bacterial CARD domain is essential for protease-mediated activation of bacterial gasdermins that promote cell death.Fine-tuning gibberellin improves rice alkali–thermal tolerance and yield
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08486-7
Precise regulation of the phytohormone gibberellin to optimal levels may not only confer alkali–thermal tolerance to Green Revolution rice varieties but may also further enhance their yield, and ATT2, by enabling the fine-tuning of gibberellins, is expected to be a potential new post-Green Revolution gene.Global meta-analysis shows action is needed to halt genetic diversity loss
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08458-x
A comprehensive meta-analysis of global terrestrial and marine genetic diversity covering more than three decades of research demonstrates rapid loss of genetic diversity and identifies conservation interventions that could mitigate this process.Enhanced energy storage in antiferroelectrics via antipolar frustration
Nature, Published online: 29 January 2025; doi:10.1038/s41586-024-08505-7
This study reports that incorporating non-polar nanodomains into antiferroelectrics greatly enhanced the energy density and efficiency.