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Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08518-2

Transcriptomic profiling of neurons from the zebrafish optic tectum identified more than 60 cell types; functional imaging revealed that response tuning, morphology and connectivity of specific cell types vary systematically with the neurons’ positions in the tissue.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08581-9

Serotonergic enterochromaffin cells of the intestine exhibit distinct sensory, secretory and physiological properties depending on their location within the complex crypt–villus architecture of the gut.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08553-z

A metalloenzyme capable of oxidatively cleaving cellulose, found in a microbial community specialized in lignocellulose degradation, could enable sustainable biofuel production.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08532-4

UM171 promotes corepressor degradation by acting as a molecular glue to induce KBTBD4–HDAC1/2 interactions with the help of inositol hexakisphosphate.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-025-08594-y

A meta-analysis of more than 1,000 studies reveals the global ecosystem functions provided by termites, ants and earthworms as they improve soil quality by making biogenic structures such as termite mounds, ant hills and earthworm casts.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08516-4

We illustrate that including data from Greenlandic Inuit can greatly reduce inequity in genomic-based healthcare in Greenland and other indigenous Arctic populations.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08535-1

A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08436-3

The altermagnetic order in CrSb films can be manipulated via crystal symmetry; the reconstructed altermagnetic order generates a room-temperature spontaneous anomalous Hall effect and designable switching modes as field-assisted and field-free modes.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08483-w

Atomically dispersed inert oxide nano-overlays on a highly active Pt/γ-Mo2N catalyst can block the redundant surface sites of γ-Mo2N responsible for surface oxidation of this reactive support and the resulting deactivation, without compromising the intrinsic activity of active Pt@Mo2N interface.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08575-7

Electrical excitability in neuroendocrine SCLC cells promotes tumour progression through action potential firing, increasing ATP demand and oxidative phosphorylation dependency, whereas non-neuroendocrine cells provide metabolic support, driving a tumour-autonomous cycle that enhances tumorigenesis and metastasis.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08490-x

Ongoing hydrogen loss from two sibling exoplanets provides support for the role of such hydrogen loss in the evolution of close-orbiting sub-Neptunes.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08408-7

A recycling strategy based predominantly on the use of water to restore and reuse valuable components from perovskite photovoltaic waste is described, with recycled devices showing similar efficiency and stability compared with fresh devices.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08554-y

Loggerhead sea turtles, which undergo long-distance migrations, can learn magnetic signatures associated with different geographic areas and have two different magnetic senses, each based on a different underlying mechanism.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08243-w

This Perspective discusses strategies and challenges for the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Consortium as it aims to catalogue the molecular and cellular phenotypes associated with null alleles of all human genes.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08474-x

A review of studies on communication between the nervous and immune systems redefines the neuroimmune connectome with a focus on health and disease, and discusses how the latest techniques can advance our understanding.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08479-6

An innovative method using superconducting sensors precisely measures the recoil energy of lithium-7 nuclei, setting a lower limit on the spatial extent of neutrino wavepackets, advancing understanding of neutrino properties and weak nuclear decays.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08410-z

Two recently discovered bird fossils from the Late Jurassic Zhenghe Fauna demonstrate that highly derived bird-like features and the origin of birds appeared much earlier in the Jurassic period than previously estimated.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08415-8

Extruded zinc alloys of dilute compositions can achieve ultrahigh strength and excellent durability when their micron-scale grain size is increased.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08533-3

We show that gain-of-function cancer mutations in the KBTBD4 E3 ligase promote neodegradation of substrates via a shape-complementarity-based mechanism, which converges with the mechanism of action of the UM171 molecular glue degrader and can be blocked by HDAC1/2 inhibitors.

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08561-z

X-ray spectroscopic observations of the Centaurus galaxy cluster with the X-Ray Imaging and Spectroscopy Mission satellite show that the hot gas flows along the line of sight relative to the central galaxy.