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Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08629-4

Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regulated by nutrient-sensing mechanisms and bacterial viability.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08612-z

A study shows that the rapid diversification of cichlids in African lakes is driven by their ability to evolve between having simple or complex teeth.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08596-w

A complete genome assembly of a crab-eating macaque, revealing 46% fewer segmental duplications and 3.83 times longer centromeres than those of humans, is presented, enhancing understanding of lineage-specific phenotypes, adaptation and primate evolution.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08631-w

Behavioural-state-dependent pyramidal neurons have a distinct pattern of long-range glutamatergic inputs, with a larger proportion of thalamic versus motor cortex inputs compared with non-behaviour-dependent neurons.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08617-8

New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social isolation and the satiation of social need during social reunion.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08636-5

Systems-level Worm Perturb-Seq of metabolic genes reveals design principles of transcriptional metabolic rewiring, many of which can be explained by a compensation–repression model.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08589-9

Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08624-9

A study reports that the structural maturation of the matrix domain of the Gag protein of HIV-1 is induced by the proteolytic release and binding of the spacer peptide SP2.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-024-08544-0

Climate models suggest that the Atlantic Meridional Overturning Circulation is unlikely to collapse this century, owing to stabilization from wind-driven upwelling in the Southern Ocean.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08622-x

The cis-regulatory functions of human accelerated regions of genomic loci and their potential contribution to human brain evolution are revealed.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08608-9

Analyses of strain-resolved metagenomics with isolate sequencing data of skin samples from residents at nursing homes suggest that skin is a reservoir for Candida auris and other multidrug-resistant bacterial species.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-024-08565-9

Emplacement of the north polar cap of Mars is investigated by combining viscoelastic deformation calculations and observations, showing that it formed over the last 1.7–12.0 Myr atop a stiff lithosphere and high-viscosity mantle (1022 Pa s), and that glacial isostatic adjustment could be further constrained.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-024-08537-z

Multiplexed entanglement distribution in a quantum network, with each node comprising multiple solid-state emitters in nanophotonic cavities, enables scalable quantum communication.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08592-0

Evolutionary modelling and expert review are applied to integrate experimentally supported knowledge accumulated in the Gene Ontology knowledgebase to create a draft human gene ‘functionome’.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-024-08549-9

An elastocaloric cooling platform is constructed based on shape memory alloys with a cellular architecture that enables cooling powers above 1 kW.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-024-08568-6

A textile fibre computer combining sensing, memory, processing and communication in a 5-g mass has been developed, enabling distributed computation on the human body through garments.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08613-y

The identification of tools dated to the time of Homo sapiens associated with microfloral evidence of wet tropical forests indicates that West African forests were occupied by humans much earlier in human evolution than previously thought.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08656-1

Two new methods, target chromatin indexing and tagmentation (TACIT) and combined TACIT (CoTACIT), enabled single-cell profiling of the epigenome and lineage tracing from mouse zygotes to blastocysts.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08620-z

Orbital hybridization in artificial atoms is achieved by altering their shape, and the anisotropy of the confining potential gives rise to the hybridization between quasibound states with different orbital quantum numbers within the artificial atom.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-024-08582-8

The interplay between geometrical and spin chiralities in three-dimensional twisted magnetic ribbons can lead to new functionalities that could allow for innovative chiral spintronics.