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VDAC2 loss elicits tumour destruction and inflammation for cancer therapy
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08732-6
VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and mitochondrial damage for improved cancer therapy.Regulated somatic hypermutation enhances antibody affinity maturation
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08728-2
Germinal centre B cells modify their mutation rate to preserve high-affinity receptors, thereby safeguarding high-affinity B cell lineages and enhancing the outcomes of antibody affinity maturation.Down-converted photon pairs in a high-<i>Q</i> silicon nitride microresonator
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08662-3
Spontaneous parametric down-conversion was used to generate narrowband photon pairs with a high spectral brightness in a high-Q silicon nitride microresonator.Convergent vocal representations in parrot and human forebrain motor networks
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08695-8
Using advanced brain-recording techniques, parrots were found to have a brain organization for vocal control similar to humans, making them an important model for studying speech and for developing potential treatments for communication disorders.Rapid emergence of latent knowledge in the sensory cortex drives learning
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08730-8
In mice, learning and performance on an auditory task is driven by higher-order signals in the auditory cortex that are no longer required when the mouse has achieved expert-level performance.Overlapping nuclear import and export paths unveiled by two-colour MINFLUX
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08738-0
High spatiotemporal precision tracking using 3D MINFLUX shows that nuclear import and export occur in overlapping regions of the central pore, providing insight into transport across the nuclear pore complex.Structural dynamics of DNA unwinding by a replicative helicase
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08766-w
Cryo-electron microscopy structures of DNA helicases in various conformations provide insight into an ATP-hydrolysis-dependent ‘entropy switch’ that drives unwinding of DNA for replication, with probable conservation across viral and eukaryotic systems.Water structure and electric fields at the interface of oil droplets
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08702-y
Raman spectroscopy measurements of water at the interface with oil droplets show a perturbed hydrogen-bond network and evidence for a strong interfacial electric field.Electroluminescence and energy transfer mediated by hyperbolic polaritons
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08627-6
Far-field mid-infrared spectroscopy reveals both the electroluminescence of hyperbolic phonon polaritons of hexagonal boron nitride excited by strongly biased graphene, and the associated radiative energy transfer through the material.Hyperbolic phonon-polariton electroluminescence in 2D heterostructures
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08686-9
All-electrical excitation of the hyperbolic phonon polaritons in hexagonal boron nitride by drifting charge carriers in nearby graphene results in electroluminescence at mid-infrared frequencies.Spatially resolved mapping of cells associated with human complex traits
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08757-x
Integration of spatial transcriptomics data with data from genome-wide association studies enables spatially resolved mapping of cells associated with human diseases and other complex traits.Oncolytic virus VG161 in refractory hepatocellular carcinoma
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08717-5
Results of a multicentre phase 1 clinical trial evaluating treatment with the engineered herpes simplex virus VG161 in advanced liver cancer indicate a good safety profile and promising efficacy.GluA2-containing AMPA receptors form a continuum of Ca<sup>2+</sup>-permeable channels
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08736-2
GluA2-containing AMPA receptors (AMPARs) are not Ca2+ impermeable, and their ability to transport Ca2+ is shaped by the subunit composition of AMPAR tetramers as well as the orientation of transmembrane AMPAR regulatory proteins and cornichon auxiliary subunits.Global sea-level rise in the early Holocene revealed from North Sea peats
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08769-7
An early Holocene sea-level curve based on data from the North Sea reveals two phases of accelerated sea-level rise owing to meltwater from the North American and Antarctic ice sheets.Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08724-6
Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous remodelling of cellular overlaps that maintain vessel integrity.Long-term studies provide unique insights into evolution
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08597-9
Long-term studies provide insights into the complex interplay between evolutionary process and pattern across multiple systems and timescales.Cooper-pair density modulation state in an iron-based superconductor
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08703-x
Pair density modulation, an unusual superconducting state whose superconducting gap is modulated by the wavelength corresponding to the lattice periodicity, is described and observed in exfoliated thin flakes of the iron-based superconductor FeTe0.55Se0.45.The somatic mutation landscape of normal gastric epithelium
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08708-6
Whole-gene sequencing of microdissected gastric glands from individuals with and without gastric cancer reveals distinct patterns of somatic mutations and provides insights into influences on the somatic evolution of the gastric epithelium.Histological signatures map anti-fibrotic factors in mouse and human lungs
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08727-3
Transcriptomic and proteomic analyses of cells and matrix along the fibrotic trajectory in mouse lung identified PI16 as an anti-fibrotic factor with potential for therapeutic application in humans.Sleep pressure accumulates in a voltage-gated lipid peroxidation memory
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08734-4
Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state of a stably bound NADPH cofactor.