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Updated: 1 hour 38 min ago

Bevel-edge epitaxy of ferroelectric rhombohedral boron nitride single crystal

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/s41586-024-07286-3

Centimetre-sized single-crystal rhombohedral boron nitride layers are achieved through bevel-edge epitaxy, and the resulting material exhibits robust, homogeneous and switchable ferroelectricity with a high Curie temperature.

Mitochondrial transfer mediates endothelial cell engraftment through mitophagy

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/s41586-024-07340-0

Under stressful conditions, mesenchymal stromal cells transfer mitochondria to endothelial cells through tunnelling nanotubes, and artificially transplanting mitochondria into endothelial cells improves the ability of these cells to engraft and to revascularize ischaemic tissues.

Frequent disturbances enhanced the resilience of past human populations

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/s41586-024-07354-8

Analysis of population decline shows that frequent disturbances enhance a population’s capacity to resist and recover from downturns and that trade-offs exist when adopting new or alternative land-use strategies.

Structural and molecular basis of choline uptake into the brain by FLVCR2

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/s41586-024-07326-y

FLVCR2 is expressed in the blood–brain barrier of mouse and human, and is the major mediator of choline uptake into the brain.

Multimodal decoding of human liver regeneration

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/s41586-024-07376-2

Harnessing single-nucleus RNA sequencing and spatial profiling, this work dissects unanticipated aspects of human liver regeneration to uncover a novel migratory hepatocyte subpopulation mediating wound closure following acute liver injury.

Stereoselective amino acid synthesis by photobiocatalytic oxidative coupling

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/s41586-024-07284-5

We report on the oxidative cross-coupling of organoboron reagents and amino acids via pyridoxal biocatalysis to produce non-canonical amino acids, uncovering stereoselective, intermolecular free-radical transformations.

Endurance exercise causes a multi-organ full-body molecular reaction

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-00585-9

A study of male and female rats has examined the biomolecular changes induced in many of their organs by eight weeks of endurance treadmill training. The findings offer insights into the many benefits to our immune, metabolic and stress-response pathways as we adapt to exercise.

Intel brings quantum-computing microchips a step closer

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01208-z

By adapting methods for fabricating and testing conventional computer chips, researchers have brought silicon-based quantum computers closer to reality — and to accessing the immense benefits of a mature chipmaking industry.

Plagiarism in peer-review reports could be the ‘tip of the iceberg’

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01312-0

Researchers say swathe of copied text could indicate a widespread problem.

We need more-nuanced approaches to exploring sex and gender in research

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01204-3

Some scientists are reluctant to investigate questions about sex and gender, particularly given today’s sociopolitical tensions around gender identity. But they should lean in and embrace the complexity.

Why it’s essential to study sex and gender, even as tensions rise

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01207-0

Some scholars are reluctant to research sex and gender out of fear that their studies will be misused. In a series of specially commissioned articles, Nature encourages scientists to engage.

Genomics reveal unknown mutation-promoting agents at global sites

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01190-6

Genetic sequencing of human kidney cancers worldwide has revealed associations between geographical locations and specific mutation patterns, indicating exposure to known and unknown mutation-promoting agents.

Allen J. Bard obituary: electrochemist whose techniques underpin clinical diagnostics, materials discovery and more

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01278-z

Innovator who pioneered scanning electrochemical microscopy, bioassays and solar fuels.

Male–female comparisons are powerful in biomedical research — don’t abandon them

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01205-2

Binary sex studies have been denounced as too simplistic, but dropping them altogether would impede progress in a long-neglected area of biomedicine.

Cells destroy donated mitochondria to build blood vessels

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01233-y

Organelles called mitochondria are transferred to blood-vessel-forming cells by support cells. Unexpectedly, these mitochondria are degraded, kick-starting the production of new ones and boosting vessel formation.

Why is exercise good for you? Scientists are finding answers in our cells

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01200-7

Decades of evidence shows that exercise leads to healthier, longer lives. Researchers are just starting to work out what it does to cells to reap this reward.

Resilience lessons from ancient societies are still relevant today

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01189-z

What lessons can we learn from the factors that govern the resilience of human populations? A large-scale analysis examining ancient societies around the world provides a detailed look at what drives sustainability.

Dad’s gut microbes matter for pregnancy health and baby’s growth

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01191-5

Altering gut bacteria in male mice revealed that microorganisms are needed for normal sperm development and offspring health. Scientists discuss the implications in terms of understanding microbes, male fertility and pregnancy.

The AI tuner

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01219-w

If music be the food of love.

Support communities that will lose out in the energy transition

Wed, 01/05/2024 - 00:00

Nature, Published online: 01 May 2024; doi:10.1038/d41586-024-01248-5

Climate campaigners and politicians rightly concentrate on the benefits of clean energy — but without more support for those who are adversely affected, the backlash will only grow.