Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.
Updated: 16 min 31 sec ago
The intrinsic substrate specificity of the human tyrosine kinome
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07407-y
An atlas of the substrate specificities for the human tyrosine kinome reveals diversity of motif specificities and enables identification of kinase–substrate relationships and kinase regulation in phosphoproteomics experiments.Chemical short-range disorder in lithium oxide cathodes
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07362-8
The introduction of chemical short-range disorder substantially affects the crystal structure of layered lithium oxide cathodes, leading to improved charge transfer and structural stability.Boron catalysis in a designer enzyme
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07391-3
A completely genetically encoded boronic-acid-containing designer enzyme was created and characterized using X-ray crystallography, high-resolution mass spectrometry and 11B NMR spectroscopy, allowing chemistry that is unknown in nature and currently not possible with small-molecule catalysts.Genome organization around nuclear speckles drives mRNA splicing efficiency
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07429-6
Nuclear speckles are shown to have a functional role in mRNA splicing, whereby dynamic three-dimensional organization of DNA around these structures mediates splicing efficiency.Ligand cross-feeding resolves bacterial vitamin B<sub>12</sub> auxotrophies
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07396-y
Two species of auxotrophic marine bacteria are shown to share precursors to synthesize the essential cofactor vitamin B12, and such ligand cross-feeding may be a common phenomenon in the ocean and other ecosystems.Structural pharmacology and therapeutic potential of 5-methoxytryptamines
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07403-2
Detailed analyses of the serotonin receptor 5-HT1A and the psychedelic 5-methoxy-N,N-dimethyltryptamine reveal the differences in receptor structural pharmacology that mediate signalling specificity, efficacy and potency, findings that may facilitate the development of new neuropsychiatric therapeutics.An atomic boson sampler
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07304-4
Boson sampling using ultracold atoms in a two-dimensional, tunnel-coupled optical lattice is enabled by high-fidelity programmable control with optical tweezers of a large number of atoms trapped in an optical lattice.Directly imaging spin polarons in a kinetically frustrated Hubbard system
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07356-6
A triangular-lattice Hubbard system realized with ultracold atoms is used to directly image spin polarons, revealing ferromagnetic correlations around a charge dopant, a manifestation of the Nagaoka effect.Self-oscillating polymeric refrigerator with high energy efficiency
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07375-3
We report on a near-zero-power flexible heat pump that uses both electrocaloric and electrostrictive properties of a tailored polymer to create a chip-scale refrigerator device.Targetable leukaemia dependency on noncanonical PI3Kγ signalling
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07410-3
Using a multimodal approach across acute leukaemias, a targetable PI3Kγ dependency in leukaemias is explored.Long-range order enabled stability in quantum dot light-emitting diodes
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07363-7
Improving the long-range order of the quantum dots in perovskite LEDs can markedly enhance their operational stability.Subaerial weathering drove stabilization of continents
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07307-1
The geological histories of Archaean regions indicate that stabilization of the Earth’s continents and the formation of cratons was driven by continental emergence and subaerial weathering.Discovery of potent small-molecule inhibitors of lipoprotein(a) formation
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07387-z
Biochemical screening and optimization identify small molecules that inhibit the formation of lipoprotein(a), and these inhibitors reduce the levels of Lp(a) in several animal models, suggesting that they could provide a therapeutic option in humans.Label-free detection and profiling of individual solution-phase molecules
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07370-8
Enhanced light–molecule interactions in high-finesse fibre-based Fabry–Pérot microcavities are used to detect and profile individual unlabelled solution-phase biomolecules, leading to potential applications in the life and chemical sciences.Computationally restoring the potency of a clinical antibody against Omicron
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07385-1
By demonstrating a computational approach to restore the clinical efficacy of a COVID-19 antibody, the potential to rapidly update clinical antibodies is explored.Decoupling excitons from high-frequency vibrations in organic molecules
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07246-x
A molecular design strategy for reducing the vibration-induced non-radiative losses in emissive organic semiconductors is realized by decoupling excitons from high-frequency vibrations.Measurement of the superfluid fraction of a supersolid by Josephson effect
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07361-9
A new method based on the Josephson effect is described, allowing to measure the superfluid fraction of a supersolid, which captures the effect of spatially periodic modulation leading to reduction in the stiffness of superfluids.Lithium tantalate photonic integrated circuits for volume manufacturing
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07369-1
Electro-optical photonic integrated circuits based on lithium tantalate perform as well as current state-of-the-art ones using lithium niobate but the material has the advantage of existing commercial uses in consumer electronics, easing the problem of scalability.Retuning of hippocampal representations during sleep
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07397-x
Using a Bayesian learning approach, a study tracks the spatial representations by individual hippocampal cells over time in freely moving rats, and provides insights into how ensemble patterns form and reconfigure during sleep.A meta-analysis on global change drivers and the risk of infectious disease
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07380-6
Reducing greenhouse gas emissions, managing ecosystem health, and preventing biological invasions and biodiversity loss could help to reduce the burden of plant, animal and human diseases, especially when coupled with improvements to social and economic determinants of health.