Superfluid stiffness of twisted trilayer graphene superconductors
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08444-3
Measurements of the superfluid stiffness in twisted trilayer graphene reveal unconventional nodal-gap superconductivity, where the superconducting transition is controlled by phase fluctuations rather than Cooper-pair breaking.The genetic origin of the Indo-Europeans
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08531-5
Ancient DNA reveals how the explosive expansion of Yamnaya steppe pastoralists began with a small community north of the Black Sea speaking ancestral Indo-European, and detects genetic links with Anatolian speakers, stemming from a common Indo-Anatolian homeland in the North Caucasus–lower Volga region.Directly imaging the cooling flow in the Phoenix cluster
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08369-x
Observations of the Phoenix cluster using the James Webb Space Telescope reveal rapid cooling in galaxy cluster cores, driven by black hole jets, with gas temperatures mapped between 105 K and 106 K and cooling rates of 5,000–23,000 M⊙ yr−1.Distributed quantum computing across an optical network link
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08404-x
The distribution of quantum computations is demonstrated between two photonically interconnected trapped-ion modules, using repeatable, deterministic teleported controlled-Z gates to perform Grover’s search algorithm.Cretaceous Antarctic bird skull elucidates early avian ecological diversity
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08390-0
A new, nearly complete fossil skull of Vegavis from the James Ross Basin, Antarctic Peninsula, provides insight into its feeding ecology and exhibits morphologies that support placement among waterfowl within crown-group birds.Metal-halide porous framework superlattices
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08447-0
Using zirconium metal–organic frameworks as the host template for directed nucleation and precise growth of metal-halide sublattices, multi-dimensional single-crystalline porous superlattices can be achieved through a one-pot synthesis.IL-27 elicits a cytotoxic CD8<sup>+</sup> T cell program to enforce tumour control
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08510-w
IL-27 promotes tumour control by preventing dysfunction and enhancing cytotoxicity of tumour-specific CD8+ T cells.Superfluid stiffness of magic-angle twisted bilayer graphene
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08494-7
Research on superconductivity in magic-angle twisted bilayer graphene reveals unconventional behaviour, an anisotropic gap and a significant role of quantum geometry, using combined d.c. transport and microwave measurements, suggesting new insights into superconductivity mechanisms.Fungal impacts on Earth’s ecosystems
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08419-4
This Review delves into the fungal kingdom, exploring the relationships among fungi, animals, plants and the environment, and investigating both the threats posed by fungi and their potential benefits.Engineering a genomically recoded organism with one stop codon
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08501-x
Ochre, a strain of Escherichia coli engineered to have a single stop codon, enables reassignment of four codons for non-degenerate functions, such as incorporation of non-standard amino acids into proteins.Limited impact of <i>Salmonella</i> stress and persisters on antibiotic clearance
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08506-6
Experiments in infected mice and tissue-mimicking chemostats show that resilience of Salmonella against antimicrobial compounds is largely a result of starvation-induced general resilience rather than survival of a small subset of hyper-resilient cells.Synthetic lethality of mRNA quality control complexes in cancer
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08398-6
PELO–HBS1L and SKI complexes in the human mRNA quality control pathway exhibit a synthetic lethal interaction and may represent novel targets for the development of cancer therapies.Quantum coarsening and collective dynamics on a programmable simulator
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08353-5
A programmable quantum simulator based on Rydberg atom arrays is used to study the collective dynamics of a quantum phase transition and observe the phenomenon of quantum coarsening.A genomic history of the North Pontic Region from the Neolithic to the Bronze Age
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08372-2
Whole-genome sequencing analysis of 81 prehistoric individuals reveals how the genetic makeup of people from the North Pontic region was influenced by waves of migration during the Eneolithic period and Early Bronze Age.SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08509-3
Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted cancers and microsatellite-unstable cancers harbouring specific mutations.Transforming US agriculture for carbon removal with enhanced weathering
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08429-2
A state-level analysis of the impact of enhanced weathering deployment on carbon sequestration on agricultural land suggests that enhanced weathering could help the USA meet net-zero 2050 goals.Topological water-wave structures manipulating particles
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08384-y
Interfering water waves can be tailored to realize topological structures, namely wave vortices, skyrmions and polarization Möbius strips, that can be used to manipulate particles floating on the water surface.A comprehensive spatio-cellular map of the human hypothalamus
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08504-8
HYPOMAP integrates single-nucleus RNA sequencing and spatial transcriptomic data to create a comprehensive spatio-cellular map of the human hypothalamus.RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08542-2
The use of two mouse models of pulmonary fibrosis helped the identification of the transcription factor RUNX2 as a regulator of the transition of alveolar fibroblasts to pathological fibroblasts.Differential protection against SARS-CoV-2 reinfection pre- and post-Omicron
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08511-9
Two distinct patterns in the protective effect of natural infection against reinfection in the Omicron variant versus pre-Omicron eras show that SARS-CoV-2 immune protection is shaped by dynamic interaction between host immunity and viral evolution.